PLACE: 319 Snedecor

SPEAKER:
Xun Gu
Department of Zoology/Genetics and
Center for Bioinformatics and Biological Sciences
 

TITLE:
Comparative Genomics: From Sequence Evolution to
Function by Statistical Modeling

ABSTRACT:

In this talk, I will discuss the software we developed (DIVERGE) to detect functional divergence of protein families. We have developed statistical models for detecting functional divergence by testing the site-specific rate difference. We have conducted some large-scale data analyses and showed that functional divergence is a general pattern. Moreover, using Caspase gene family as an example, we show the structural-bases of the functional divergence that can be detected from DNA sequences analysis, using posterior analysis. Its potential application for functional genomics and further investigations for improving statistical modeling are discussed.
 

COFFEE: 3:45 p.m., 104 Snedecor Hall