LOCATION:   319 Snedecor

 

SPEAKER:   Rohan L. Fernando, Department of Animal Science, Iowa State University

TITLE: Use of linkage disequilibrium for fine mapping quantitative trait loci

ABSTRACT:

Computer simulation was used to study the performance of a recently proposed, multi-locus method for fine mapping quantitative trait loci (QTL) that assumes closely linked loci are in linkage disequilibrium (alleles at closely linked loci are dependent).  Surprisingly, simple linear regression on the genotypes at individual loci was almost as effective as the multi-locus method that used information from 10 loci simultaneously.  Further investigation revealed that the multi-locus method gave best results when information from only four loci was used jointly.  The purpose of this talk is to seek an explanation of these seemingly paradoxical results COFFEE: 3:45 p.m., 104 Snedecor Hall