Speaker: Terry Therneau, Mayo Clinic
Title: Random Effects and Survival Models
Date/Time: Monday Nov 15 at 4:10PM
Place: Snedecor 319

Abstract:

Over the last few years our group has added random effects to the Cox model routines, developed here, that are at the core of the Splus and R survival packages. These additions have all been in response to particular data analysis problems that we have faced.

The routines have been found to be particularly useful in studies with a familial genetics component, and nicely compliment the familiar LOD score methods for binary and continuous traits. This talk will present some of those cases, along with open questions for further research. This includes computational issues (speed, accuracy of the approximations, etc.), the effect of ascertainment bias, sample size, and choice of distribution.

There are almost certainly connections to work in both reliability and animal breeding that could fruitfully be pursued. It is hoped that this talk can spark discussion and ongoing collaboration.