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Seminars: Other

Gene set testing and gene selection using permutation testing procedures

Date: Friday, October 09
Time: 4:10 pm -- 5:00 pm
Place: Snedecor 2113
Speaker: Megan Orr

Abstract:

In microarray analysis, multivariate permutation testing has been shown to be a powerful tool for identifying differentially expressed gene sets.  Because a given gene set may involve tens, hundreds, or even thousands of genes, it is possible that a difference among the high-dimensional multivariate distributions corresponding to multiple treatments may be due to only a relatively small subset of all genes in a gene set.  We explore whether permutation techniques can be used to identify these small gene subsets responsible for high-dimensional distribution differences.